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Genome Wide Association Studies

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  Good News For Researchers !!!
Genome Wide Association Studies (GWAS) training/workshop is to introduce researchers to the basic principles of analyzing genotyping individuals at common variants across the genome using genome wide SNP by next-gen sequencing approaches. The most important NGS file formats (fastq, sam/bam, bigWig, etc.) are introduced and one proceeds with first hands-on analyses (QC, mapping, visualization).

Goals :

In this hands-on session we will align example data from an GWAS experiment against the genome, variation calling and statistical GWAS analysis with significant pvalue for highly associated mutations filtration. Also combining Computer aided drug designing techniques to validate in-silico for wild type and mutant mutation detected with highly associated mutation from GWAS.


Participants will be introduced with its applicability to real-time data analysis problem. All our training content is as per industrial requirement and 100% practical exposure which will help candidate to make their better career in the field of bioinformatics.

Hurry up and register soon...To become expert in Bioinformatics !


## 10% Discount if you register before 25th November, 2020. Hurry up!!


Genome Wide Association Studies (GWAS)Training Program


Training Information
Period of Training Offline - 21 Days Training   [ 2 Hours Daily [ Monday To Saturday ] ]
Online - 21 Days Training   [ 2 Hours Daily [ Monday To Saturday ] ]
Registration Open
(Training can be started on any date any timing as per the candidate convenience)
Module - I Advanced Bioinformatics
Topics - Introduction to Bioinformatics & Genomics
- Understanding Genomics Bioinformatics
- Databases & tools (NCBI, UCSC, BLAST, BLAT etc)
- Gene Prediction
- Genome Annotation
- Genome Visualization
- Programming Python
- Linux based commands & Tools for GWAS data analysis
Module - II GWAS
Topics - Overview of NGS & variation calling & GWAS
- Data Retrieval (NCBI SRA) & Introduction to data types
- Read Quality Check (FastQC & Cutadapt)
- Alignment of reads using reference Genome (BWA/Bowtie)
- Understanding Mapping Output(SAM/BAM, Samtools & Bedtools)
- Variant detection using GATK
- Visualization of variation with IGV
- Complete annotation and variant effect prediction(Ensemble VEP)
- Example VCF data from population Case & Control for GWAS study
- VCF file format
- Quality control of Samples, Variants and genotypes
- GWAS analysis using Hail pipeline
- Normalisation for confounding caused by population stratification
- Visualisation of GWAS results (Manhattan plot and QQ-Plot)
- Disease associated mutation Interpretation

Module - III (In-silico Validation Wild type Vs Mutant)
Topics -Retrieving the sequence and protein structure from PDB (wild type)
-Mutating the sequence and building homology model using servers like SwissMODEL, PHYRE2, I-TASSER, etc. (if mutant structure not available in PDB)
-Molecular Docking (wild type and mutant) using AutoDock vina
-Molecular Dynamics Simulation (wild type and mutant) using VMD-NAMD
-Analysis and report construction
Eligibility B.Sc/B.Tech/M.Tech. / M.Sc. /Ph.D /PostDocs/Any Life Sciences in Biological Science, Computer science, Pharmacy, Agriculture, Biotechnology, Molecular biology, Medicine, clinical research and other relevant Qualification in the life sciences areas are eligible.
Certificate All the participants will receive certificates on successful completion of training
Place ArrayGen, Pune, India
Contact info@arraygen.com



    

Registration is now open please request to sign up to reserve your place! If you are interested, you can mail us at info@arraygen.com. We hope to see you in this new year. Dont miss this opportunity.



 
 
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